About MDAiRE™

Skin Science you can trust. Results you can see.

MDAiRE was created by Dr. Kappel who has spent over 15 years studying what skin actually needs at a cellular level. Every ingredient is chosen with intention, and every formulation held to a clinical standard.

This is skincare built on evidence. ARE stands for Antioxidant Response Element; one of the body's most powerful anti-aging pathways. The "i" represents its induction at a cellular level. When activated, the AIRE transduction pathway triggers protective gene expression that defends skin cells against oxidative stress, a primary driver of aging. Dr. Kappel believes healthy skin always results in beautiful skin.

The most effective skincare doesn't react to aging... It interrupts it.

Credentials

Medical degree

UC Irvine College of Medicine — highest honors

Residency

Dermatology — UCLA

Fellowship

Procedural Dermatology — UC Davis & Laser & Skin Surgery Center of Northern California

Faculty

Clinical Instructor & Professor of Dermatology — UCLA

What we stand for

What we stand for

  • Science over marketing

    Our ingredient lists aren't built around what sounds good. They are built around what research confirms works. If science doesn't support it, it doesn't belong on your skin.

  • Cellular Skin Health

    Real results happen below the surface. We formulate to support the health of the skin cell itself, because skin that functions optimally at a cellular level looks, feels, and ages differently.

  • Anti-Aging at the Source

    MDAiRE targets aging where it begins. By activating the AIRE transduction pathway, the skin's own Antioxidant Response Element; we trigger protective gene expression that shields cells from oxidative stress before damage can take hold.

What we formulate without

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  • Cruelty-Free

    Never tested on animals

  • Paraben-Free

    Clean formulations

  • Fragrance-Free

    No synthetic fragrance

  • Phthalate-Free

    No harmful additives

Not sure where to start?

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